And with that, he ceased twitching.

They were forced to mean our estate to the Queen of England.

[…] with words of sweetest kindness and consolation, he soothed and tranquilised me.

On the other hand, drugs with drowsiness as a side-effect (eg certain types of analgesia, antidepressants) are best administered in the evening so that patients can sleep off the effect and be alert the following day.