He's as set in his ways now as a little old man.

You're bloody berko, Koko! And who's driving? Manny? He's more round the bend than you!

Hang those lights from the ceiling.

Essentially, metformin has little ability to inhibit uroepithelial transformation, but could almost completely block progression of preneoplasms or non-invasive tumors, because no invasive cancer and sarcoma was observed in metformin-treated rats and the tumors in metformin-treated group were limited at the stages of dysplasia, papillary tumor or CIS.