The researcher counted several nucleoli in the cell samples to study ribosome production.

Under the electron microscope, the nucleoliform granules clustered near the nucleus, indicating active ribosome assembly.

During ribosome biogenesis, nucleolin binds precursor rRNA and coordinates its processing and maturation.

During the experiment, the team found that nucleolins concentrated at sites of active ribosomal RNA synthesis.

The nucleolic staining pattern revealed active ribosomal RNA synthesis within the cell nuclei.

The researchers formulated a nucleolipid to improve cellular delivery of the therapeutic RNA.