Last Updated :2025/11/26

Kulinkovich reaction

Noun
Japanese Meaning
有機合成法の一種。エステルとβ-水素を有するグリニャール試薬およびチタン(IV)アルコキシド(例えばチタンイソプロポキシド)から原位で生成される二アルキル二アルコキシチタン試薬を反応させ、シクロプロパノールを合成する反応
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エステルを、β位に水素を有するグリニャール試薬とチタン(IV)アルコキシド(例えばイソプロポキシチタン)からその場で生成されるジアルキルジアルコキシチタン試薬を用いてシクロプロパノールに変換する有機合成法は、エステルをシクロプロパノールへと変換する。

plural

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(organic chemistry) The organic synthesis of cyclopropanols via reaction of esters with dialkyldialkoxytitanium reagents, generated in situ from Grignard reagents bearing hydrogen in beta-position and titanium(IV) alkoxides such as titanium isopropoxide.

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Kulinkovich reaction

The Kulinkovich reaction converts esters into cyclopropanols by employing dialkyldialkoxytitanium species generated in situ from Grignard reagents that possess a beta-hydrogen together with titanium(IV) alkoxides such as titanium isopropoxide.

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The Kulinkovich reaction converts esters into cyclopropanols by employing dialkyldialkoxytitanium species generated in situ from Grignard reagents that possess a beta-hydrogen together with titanium(IV) alkoxides such as titanium isopropoxide.

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