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In contrast, following intramyocardial delivery, both micro-tissue particles and dispersed cell grafts coupled electrically with the rat heart and could be paced through the host tissue up to 6.5 Hz. This suggests that electrophysiological adaptation of hESC-derived cardiomyocytes occurs in vivo and supports the use of the rat ischemia/reperfusion model for cardiac remuscularization studies using hPSC-derived cardiomyocytes.

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