Last Updated：2022/12/24
In contrast, following intramyocardial delivery, both micro-tissue particles and dispersed cell grafts coupled electrically with the rat heart and could be paced through the host tissue up to 6.5 Hz. This suggests that electrophysiological adaptation of hESC-derived cardiomyocytes occurs in vivo and supports the use of the rat ischemia/reperfusion model for cardiac remuscularization studies using hPSC-derived cardiomyocytes.
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In
contrast,
following
intramyocardial
delivery,
both
micro-tissue
particles
and
dispersed
cell
grafts
coupled
electrically
with
the
rat
heart
and
could
be
paced
through
the
host
tissue
up
to
6.5
Hz.
This
suggests
that
electrophysiological
adaptation
of
hESC-derived
cardiomyocytes
occurs
in
vivo
and
supports
the
use
of
the
rat
ischemia/reperfusion
model
for
cardiac
remuscularization
studies
using
hPSC-derived
cardiomyocytes.
