(pathology) The abnormal hardening of body tissues, such as an artery. / Inability to create change or excessive resistance to change.

(pathology) A chronic disease of the brain and spinal cord characterized by changes in sensation, visual problems, weakness, depression, difficulties with coordination and speech, impaired mobility and disability.

(neurology, pathology) name of a number of chronic, progressive nervous diseases.

A rare disease that causes benign tumors to grow in the human brain, kidneys, heart, liver, eyes, lungs and skin, caused by a mutation in the genes for the tumor growth suppressor proteins hamartin and tuberin.

(neurology, pathology) A chronic, progressive disease characterized by degeneration of the central nervous system and the loss of voluntary muscle control.