The kinase hyperphosphorylated the tau protein, accelerating its aggregation into neurofibrillary tangles.

Researchers observed hyperphosphorylated tau proteins in the hippocampus, which disrupted microtubule stability and contributed to neuronal loss.

When stressed, tau protein hyperphosphorylates and aggregates into neurofibrillary tangles associated with Alzheimer's disease.

Under prolonged oxidative stress, the kinase can hyperphosphorylate the tau protein, accelerating neurodegeneration.

Researchers observed frequent hyperphosphorylations of tau protein in the affected brain tissues, suggesting a link to neurodegeneration.

The researchers observed hyperphosphorylation of the protein following prolonged exposure to the kinase activator.

The hyperphosphorylating kinase variant accelerated neuronal degeneration in the mouse model.