The inner sanctum of the Temple in Jerusalem. / (by extension) The most sacred place within a sacred building. / (informal, humorous) One's private retreat, inner sanctum.

Alternative spelling of Holy of Holies

plural of holy. Used almost exclusively in Holy of Holies.

Dedicated to a religious purpose or a god. / Revered in a religion. / Morally perfect or flawless, or nearly so. / Separated or set apart from (something unto something or someone else).

(slang) An expression of astonishment and awe.

(archaic) A thing that is extremely holy; used almost exclusively in Holy of Holies.

(countable) Used in connection with His or Your to address the pope.

The state or condition of being holy.

Archaic spelling of holy.

Alternative letter-case form of holy used when referring to an important figure, such as God, or to an important item or event.