Last Updated：2025/11/21
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The gene's function was lost after a frameshift mutation altered all downstream codons, producing a nonfunctional protein.
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The gene's function was lost after a frameshift mutation altered all downstream codons, producing a nonfunctional protein.
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Related words
frameshift mutation
Noun
countable
uncountable
(genetics)
A
genetic
mutation
that
either
inserts
or
deletes
a
number
of
nucleotides
that
is
not
divisible
by
three
(i.e.,
a
non-integer
number
of
codons),
altering
the
reading
frame
of
the
portion
of
the
gene
downstream
of
the
mutation
and
causing
it
to
code
for
a
completely
different
protein
sequence.
Japanese Meaning
遺伝学における突然変異の一種で、三の倍数でないヌクレオチドの挿入または欠失により、変異部位以降の遺伝子の読み枠（コドンの配列）がずれてしまい、全く異なるタンパク質配列が生成される現象を指す
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