Last Updated：2025/12/31
Sentence
Although
speculative,
several
observations
favor
this
hypothesis,
including
the
overexpression
of
Cyclin
D1
and
c-MYC
before
dysplasia
even
occurs
[16,17]
and
the
transcriptional
regulation
of
intestinal
markers
by
β-catenin
activity
[18,19],
along
with
the
efficiency
of
Wnt
signaling
to
intestinalize
human
esophageal
keratinocytes
in
vitro
[20]
.
Quizzes for review
Although speculative, several observations favor this hypothesis, including the overexpression of Cyclin D1 and c-MYC before dysplasia even occurs [16,17] and the transcriptional regulation of intestinal markers by β-catenin activity [18,19], along with the efficiency of Wnt signaling to intestinalize human esophageal keratinocytes in vitro [20] .
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