Last Updated：2025/12/31
Sentence
This
signaling
complex,
the
so-called
myddosome,
assembles
in
a
hierarchical
manner
so
that
IRAKs
can
associate
with
tumor
necrosis
factor
receptor-associated
factor
6
(TRAF6),
which,
via
a
complex
signaling
cascade,
ultimately
enables
NF-κB
to
translocate
into
the
nucleus
where
it
regulates
gene
transcription.
Quizzes for review
This signaling complex, the so-called myddosome, assembles in a hierarchical manner so that IRAKs can associate with tumor necrosis factor receptor-associated factor 6 (TRAF6), which, via a complex signaling cascade, ultimately enables NF-κB to translocate into the nucleus where it regulates gene transcription.
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