However, hyperghrelinemia is unlikely to arise from leptin resistance, as ghrelin levels are not elevated in obese subjects homozygous for an inactivating LepR mutation.

Don't be a scaredy pant, you got this!

He saw Dr. Simon, a typical French scientist, with glasses, a pointed brown beard, and a forehead barred with those parallel wrinkles which are the penalty of superciliousness, since they come through constantly elevating the eyebrows.

Only a rough sketch will be attempted here—partly because this topic could fill up a book of its own and partly because the author does not have a bookful or even a chapterful of ideas on the subject.