Last Updated：2022/12/24
The transcription factor T-bet promotes naive CD8 + T-cell differentiation to effector cytotoxic T lymphocytes (CTL) [13 –14 ], expressing CD25 (IL-2R-α), IL-12 receptor (IL-12R) and IFN-γR. TLR2, forming heterotypic associations with TLR1 or TLR6, recognizes triacetylated or diacetylated lipopeptides, respectively [15 –17 ].
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The
transcription
factor
T-bet
promotes
naive
CD8
+
T-cell
differentiation
to
effector
cytotoxic
T
lymphocytes
(CTL)
[13
–14
],
expressing
CD25
(IL-2R-α),
IL-12
receptor
(IL-12R)
and
IFN-γR.
TLR2,
forming
heterotypic
associations
with
TLR1
or
TLR6,
recognizes
triacetylated
or
diacetylated
lipopeptides,
respectively
[15
–17
].
