Last Updated：2022/12/24
In general, compounds having a brenzcatechin moiety were found to be active, but also cytotoxic against host cells due to oxidation and formation of a highly reactive Michael system, whereas analogue compounds without the 3,4-dihydroxy substitution at the phenyl ring (e.g. compound 1 ) were still active but less toxic.
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In
general,
compounds
having
a
brenzcatechin
moiety
were
found
to
be
active,
but
also
cytotoxic
against
host
cells
due
to
oxidation
and
formation
of
a
highly
reactive
Michael
system,
whereas
analogue
compounds
without
the
3,4-dihydroxy
substitution
at
the
phenyl
ring
(e.g.
compound
1
)
were
still
active
but
less
toxic.
