Last Updated：2022/12/24
The effect of vitamin D on ovarian granulosa cells responsible for steroidogenesis, as well as on immune system regulation, was established after finding 1-α-hydroxylase and VDR receptors in deciduae, placentas, ovaries, endometriums and pituitary glands, and was confirmed in vitro by demonstrating active metabolites of vitamin D such as 1,25[OH]2D and 24,25[OH]2D in mentioned tissues [14,15,16,17,18].
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The
effect
of
vitamin
D
on
ovarian
granulosa
cells
responsible
for
steroidogenesis,
as
well
as
on
immune
system
regulation,
was
established
after
finding
1-α-hydroxylase
and
VDR
receptors
in
deciduae,
placentas,
ovaries,
endometriums
and
pituitary
glands,
and
was
confirmed
in
vitro
by
demonstrating
active
metabolites
of
vitamin
D
such
as
1,25[OH]2D
and
24,25[OH]2D
in
mentioned
tissues
[14,15,16,17,18].
