This understanding is key to the generative medicine of the future. Haseltine (2000) sees four phases in developing generative medicine.

If it is a boy, and I know it is, then naming him Charlie is also a way of remembering, but remembering people in my family, who may not be all rich and smart like the Willets is, but we don't got no nastyass old psycho killers in our family tree neither; […]

Then I'll fulfill his deepest fannish craving, revealed only to a few intimates in the pages of Void #29. Yes, I'll take Terry Carr to the First Fandom Party. Surrounded by REAL Old Fen and Tired, he'll be exposed for the ungafiate he really is.

It's really easy to start a genzine. All you need are a couple of neos with lots of time and enthusiasm; a couple of older fen with experience and enthusiasm (not to mention enough fannish contacts to make up a mailing-list); and a certain amount of mood-enhancers and sheer lunacy to get you to the point at which the thing stops being a great idea for Real Soon Now, and starts being a reality. A lot of crudzines are born that way.