Reid et al. in 2015 conducted a comprehensive study on basicranial malformations in a holoprosencephalic foetus with trisomy 18 (Edwards' syndrome) with synophthalmic cyclopia and alobar holoprosencephaly.

In the area of the typography, or to be more precise the microtypography – the details of how the signs and spaces relate – there was a chance to create something new.

Self-constructed personae online (unlike the offline variety) can be abandoned or re-created at will; cybersuicide may simply provide the clearest path to a fresh start.

What we look for in genre writing, Mr. Updike suggested, is exactly what the critics sometimes complain about; the predictableness of a formula successfully executed.