Travellers over the London & North Western main line in bygone days will need no reminder of the pattering of cinders on the carriage roofs, the fountains of sparks from the chimneys at night and the distance from which the exhaust of approaching locomotives could be heard, due to the fierceness of their blast in such conditions.

But look now into the weltered hearts and blighted memories of those whom we have gathered from out of the thousands of the lost and wretched.

Crystals of phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6) from the yeast Saccharomyces cerevisiae were grown by the vapor diffusion hanging-drop technique, using ammonium sulfate as the precipitant.

The 1992 Protocol amended the definitions of other terms, including ‘ship’, ‘oil’ and ‘incident’: Art. 2.