For on the spoile of women he doth live, / Whose bodies chast, when ever in his powre / He may them catch unable to gainstrive, / He with his shamefull lust doth first deflowre, / And afterwardes themselves doth cruelly devoure.

However, given the phenomenon of triallelism, it is no longer possible to be certain that the recurrence risk in an affected family will be as high as 25 per cent as it may be a requirement in up to 10 per cent of pedigrees for three mutant alleles to co-segregate.

But there are surprises, too, like the spooky Live/Dead deep cut “Death Don’t Have No Mercy...

The mean family has 2.4 children.