The RARβ2 promoter, containing several high-affinity RA-responsive elements (RAREs), is normally mediated by a dynamic histone deacetylase (HDAC) and histone acetyltransferase (HAT) balance in the presence of physiological levels of RA. However, increased level of histone deacetylation was observed during epithelial cell tumorigenesis and appropriate level of histone reacetylation at RARβ P2 can lead to reactivation of endogenous RARβ2 transcription [44 ].

Mr. Spenlow told me this day week was Dora's birthday, and he would be glad if I would come down and join a little picnic on the occasion. . . . I think I committed every possible absurdity in the way of preparation for this blessed event.

In a few weeks he [William III of England] had changed the relative position of all the states in Europe, and had restored the equilibrium which the preponderance of one power had destroyed.

A ground electrode located between Fpz and Fz. The electro-oculogram (EOG) was recorded bipolarly from two electrodes placed at the outer canthi of the right eye and below the left eye.