Represented pictures are shown from 2 wounds in each group at each day Our results reveal that the novel naphthochalcone derivative TDPN show faster wound closure and matrix remodeling (Figs. 5 and 6 ) via promoting the migration but not the proliferation of keratinocytes (Fig. 2 ).

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Secondly, most (64/87, 82%) of the patients received conventional radiation therapy, while with the development of stereotactic body radiotherapy, the treatment to the multimetastatic lesions, especial to the pulmonary oligometastases, might achieve better results [18 ].

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