The Fc variants contained two mutations (C228S and C231S) in the hinge region to exclude Fc homodimerization by eliminating the natural disulfide bonds in the hinge region and an N297Q mutation to avoid yeast hypermannosylation by removing the N-linked glycosylation site in the CH2 domain.

The government is unwilling to bail out the failed bank.

She's a total grammar Nazi.

She gestured out of the window wall. Unless it was a real professional who yomped in over the fields, the only way to get here is to drive through the village. And believe me, that's not so easy.