Since 1935 when Domagk demonstrated that prontosil provided effective therapy in a murine pneumococcal infection model, the use of animal infection models has become an integral part of the evaluation of new antimicrobial agents and new therapeutic approaches for clinical trials in humans.

Since Zappa treats subject matter, dialogue, and song as musical material, Permanent Damage has a casual off-color quality. Permanent Damage and An Evening with Wild Man Fischer were works of oddball sociology as much as they were rock and roll records.

It's worth keeping a dictionary around in case you come across an unfamiliar word.

In this report, we describe a patient with a dual-chamber pacemaker with neglected or unresolved dyssynchronization that occurred 2 years after implantation.