Because synapse loss and dysfunction occur before fibrillary tau tangles emerge in the tauopathy mouse AD model[20 ], VAChT may be used as a possible in vivo target for diagnoses of AD. It has been shown that vesamicol (2-(4-phenylpiperidino) cyclohexanol) binds to the ACh transporter on presynaptic acetylcholine storage vesicles and inhibits ACh uptake into the vesicle[21 ,22 ].

He wasn't lying because, truth be told, I looked a lot like Halle Berry, only I was much thicker in all the right places and I was way more ghetto than Halle. And I had the tattoos and the attitude to match.

Every six months, spoonfuls of castor oil were administered to combat constipation.

When it had advanced from the wood, it hopped much after the fashion of a kangaroo, using its hind feet and tail to propel it, and when it stood erect, it sat upon its tail.