The external circumstances are greatly different.

You must draw [the horse] in his career with his manage, and turn, doing the corvetto, leaping &c..

Briefly, a Camk2α promoter was used to drive expression of the tetracycline transactivator protein (Camk2α-tTa), and a tetracycline responsive promoter was used to drive ΔNLS-hTDP-43 expression (tetO-ΔNLS-hTDP-43) such that ΔNLS-hTDP-43 protein expression was inhibited by doxycycline in bigenic mice (Camk2a-tTa x tetO-ΔNLS-hTDP-43).

Other unlucky accidents happen in these seas to vexe them, as when (in most becalmings) they swim in the bearing Ocean, the greedy Tuberon or Shark arm'd with a double row of venemous teeth pursues them ….