An increasing quantity of evidence supports a force-driven mode of activation of the Notch signalling pathway, whereby exposure of the critical S2 site in the Notch NRR occurs upon mechanical unfolding of the protein during transendocytosis of the Notch extracellular domain into the ligand presenting cell.

Gimme the tooter. Dan took the tin dinner-horn, but paused before he blew.

If someone comes and asks for the ticket, just give it to them.

Due to Non-Disclosure Agreements, he was unable to confirm too much regarding the work on the '92s', […].