The fact that similar cortical abnormalities can be experimentally induced in monkeys has allowed Michael Merzenich and his colleagues in San Francisco to explore an animal model of focal dystonia, and to demonstrate the abnormal feedback in the sensory loop and the motor misfirings that, once started, grow relentlessly worse.

His osteoporosis first manifested as pain in his hips.

At present I am all upside down—nohow—bebothered—& can only write this much.

He built the Summit, so as to have no neighbours. And Lady Warren couldn't abide It. She was always jawing him about it, and they had one awful quarrel, in his study.