Isatin reacts with formaldehyde and a variety of amines in the Mannich reaction to give their respective bases (10), in the absence of an amine, isatin and substituted isatin with formaldehyde give hydroxymethyl isatins (11).

You know how matters stand, dear, said he. I have explained it also to our friends here. You're not afraid are you? It won't be painful, George? No more than laughing-gas at the dentist's.

Reduce all to a very fine Powder, searsing the same through a Tiffany Searse, as you should the former.

The Province of Xenſi extends to the Kingdom of Preſter John. Caſcar and Thebet, which the Chineſes in a general Name call Sifan it is a large Province, and is divided into eight Counties, having one hundred and eighty Cities: Sigan is the Metropolis of the whole, ſeated on the River Guei, in a moſt pleaſant and delightful place, of a noble Proſpect, and good Trade.