The TGF/Smad pathway appeared to play a role in this process, and we hypothesize that high-glucose peritoneal dialysis solutions, particularly bioincompatible peritoneal dialysis solutions, activate this pathway which may contribute to the observed changes in the peritoneum.

I am not interested in the why, but in the how.

Sally Taylor and friends did, and produced Grape Expeditions in France (Springfield Books, £5.95) an introduction to the “bicyclable wine regions of France”.

“Uck,” he said. “I mean, you... you've got to be kidding.”