[…] Munoz et al. first proposed the following scaffold filling problem (on multichromosomal genomes with no gene repetition) as follows[…]. Given a complete (permutation) genome R and an incomplete scaffold S, fill the missing genes in R – S into S to have S′ such that the genomic distance […] between R and S′ is minimized. It was shown that this problem can be solved in polynomial time.

“There’s nothing wrong with your dog,” she said. “Then why was he wailing like that? I’ve never heard an animal make such a god-awful noise.” “It’s just something that shibas do,” Dr. Cho replied. “Get used to it. He was probably happy to see you. Had you been away for a while?”

It gives me a lot of pleasure to be here tonight.

Local signaling from adjacent epithelia specify prechondrogenic fate in neural crest-derived mesenchyme, which then differentiate into chondrocytes several days later [1 ].