derangement

His [James Stewart's] postwar roles, full of myopic obsession, stalkerish derangement, and a desire for vengeance, don't seem like ground Hanks is willing to cover.

Young as he was at the time, he had seen the imprudence of Mr. Granard's way of living; he had often remonstrated, and the death of his father, with the subsequent derangement of his affairs, had alone prevented his following up his advice with such assistance as would have made it effectual.