woe

Thus saying, from her side the fatal key, / Sad instrument of all our woe, she took.

And I beheld, and heard an angel flying through the midst of heaven, saying with a loud voice, Woe, woe, woe, to the inhabiters of the earth by reason of the other voices of the trumpet of the three angels, which are yet to sound!

Can there be a woe or curse in all the stores of vengeance equal to the malignity of such a practice?