upset

I’m sure the bad news will upset him, but he needs to know.

Introducing a foreign species can upset the ecological balance.

But this argument, which first Anaxagoras and later Eudoxus and certain others used, is very easily upset; for it is not difficult to collect many insuperable objections to such a view.

Truman upset Dewey in the 1948 US presidential election.

The carriage upset when the horse bolted.

with sail on mast upset