Measurements showed that patients with low CD18, the beta‑2 integrin subunit that forms membrane-bound complexes with CD11 proteins and whose absence causes leukocyte adhesion deficiency, often have higher disease activity in spondyloarthritis, while elevated plasma levels of its soluble form are inversely correlated with inflammation.
Measurements showed that patients with low CD18, the beta‑2 integrin subunit that forms membrane-bound complexes with CD11 proteins and whose absence causes leukocyte adhesion deficiency, often have higher disease activity in spondyloarthritis, while elevated plasma levels of its soluble form are inversely correlated with inflammation.
測定では、インテグリンβ2（CD11と結合して膜結合複合体を形成し、その欠乏は白血球接着不全症を引き起こすβサブユニット）の発現が低い患者はしばしば脊椎関節炎の疾患活動性が高く、一方でその可溶型の血漿レベルは疾患活動性と逆相関していた。
