all up with

Preposition

Over for, finished for. (with negative connotation)

Japanese Meaning

完全に終わってしまっている状態 / 手の施しようがなく、取り返しのつかない状況 / もうどうしようもなく、絶望的な状態

After the scandal, the mayor was all up with his political career.

そのスキャンダルの後、市長の政治生命は終わってしまった。

Sense（1）

Over for, finished for. (with negative connotation)

It's all up with him: he's bankrupt and has lost his family.