DPS

Initialism of Delivery Point Sequence (a system of automated letter sorting used by the United States Postal Service.)

(video games) Initialism of damage per second (a standard way to calculate the damage dealt to other players or creatures in online role-playing games.)

(by extension, video games) A player or unit whose primary role is to deal the maximum amount of damage possible (as opposed to holding the attention of the enemy, healing, or other tasks).

(nuclear physics) Initialism of disintegration per second.

Initialism of designated premises supervisor.