She seems to not know which end is up when she's asked to make basic decisions.

When her landlord raised the rent and her savings were gone, Maria did not know which way to turn.

Amid the storm, she felt a deep peace which passeth understanding settling over her.

After the storm, she felt a profound peace which passes understanding wash over her.

Before making a public statement, the committee always checks which way the wind is blowing.

After three days without sleep, I didn't even know which way is up.

When hiring new managers, we make sure they know which end is up before giving them full responsibility.

She had known which end is up long before she wrote the manual.

After three chaotic weeks at the startup, she finally knew which end is up and could start organizing the team.

Everyone trusts Marcus because he knows which end is up when a crisis hits.