(informal) Expresses dismay or annoyance, especially at misfortune.

(idiomatic) To make one's best effort or attempt; to try as hard as possible.

(idiomatic) So what? Who cares? Expresses disinterest, disregard or lack of concern.

(idiomatic) To deserve or merit, as the consequences of one's actions.

(idiomatic) To suffice; to be effective or successful.

(UK, idiomatic, humorous) Expresses disbelief.

(slang) Aware of current trends and fashions. / (slang) Attentive, alert; often encountered in the negative ‘not with it’ - not understanding, not alert

To have accomplished all there is to do; to have no further work or difficulty. / To have achieved a lifestyle characterized by good fortune and comfort.

(idiomatic, colloquial) To be authentic, true to oneself; to be cool. / (idiomatic, colloquial) In the imperative, an exhortation used as a departing salutation.

Used other than figuratively or idiomatically: see get, it, on. / (slang) To have sex. / (slang) To engage in a fight. / (idiomatic) To hurry up; to get a move on.