That was an insane in the membrane idea that somehow worked.

In the 19th century, physicians studied general paralysis of the insane as a form of neurosyphilis that affected cognition and behavior.

In the late 19th century, physicians often diagnosed patients with general paresis of the insane after observing progressive cognitive decline and mood changes.

The constant buzzing of the fluorescent lights will drive someone insane if it goes on all day.

The constant dripping of the faucet drives someone insane after a while.

The neighbor's dog had driven someone insane with its barking every night for weeks.

Her habit of tapping the pen during long meetings drove someone insane.

Her nonstop questions and corrections are driving someone insane.