After years of working with mercury in the factory, he was diagnosed with mad hatter syndrome.

Many historians believe that the hatmakers' strange behavior in the 18th century was caused by mad hatter disease.

Although his schedule looks random, there is a method to one's madness: he works in short bursts to avoid burnout.

After the referee blew the final whistle on the wrong player, the coach was mad as a meat axe.

She was rip-snorting mad when she discovered someone had keyed her car.

When the neighbors started blasting music at dawn, he was mad as a box of frogs.

The neighbor's dog barking through the night will drive someone mad.

When she found out someone had scratched her new car, she was mad as a wet hen.

If you keep reorganizing every file for hours, that way madness lies.

Tourists still whisper about the strange behaviors of Mad King George during tours of the royal palace.