Any product thought to be the best of its type.

(derogatory) A person of mixed racial parentage or ancestry, especially one of mixed white and American Indian parentage (metis, métis, Metis, Métis). / A hybrid animal or plant.

(of a person, derogatory) Having dual heritage; having mixed racial parentage or ancestry.

An offspring produced by cross-breeding.

To breed separate strains of the same species in order to create new traits. / To breed members of similar albeit distinct species, for example, horse X donkey = mule

Of or pertaining to the offspring produced by cross-breeding.

Third-person singular simple present indicative form of cross-breed

(idiomatic, of a habit, personal characteristic, etc.) To establish or ingrain firmly within someone's nature.

A member of the Half-Breeds, a former Republican political party during the Gilded Age.

Third-person singular simple present indicative form of breed in the bone