(colloquial, in rhetorical questions or salutations) What's wrong with; what's the problem or matter with. Said to express that the behaviour of someone, or operation of something, is out of the ordinary or problematic.

(idiomatic, colloquial, with up in the sense of "of concern") What’s the matter? What is the problem? What is wrong?

(idiomatic) furthermore, or in addition, moreover.

What is the time of day? (used to request for the current hour and approximate number of minutes after the hour)

Used to make a suggestion. / Used to ask someone to consider something or someone that they have apparently not considered. / To repeat a question but referring to a different subject or object.

(idiomatic, Britain, colloquial) An intensified version of what or huh.

(idiomatic, informal) A greeting, similar to how are you?; what's happening?; what's up?; what's new?

Contraction of what is more.

(idiomatic) What is the purpose or advantage of

(idiomatic) what are the advantages of (something) to me, personally?